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Characterization of cell surface antigens expressed in the HMA-1 breast cancer cell line.

作者信息

Ohuchi N, Harada Y, Masuko T, Matano S, Mori S

机构信息

Second Department of Surgery, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Surg Today. 1995;25(3):244-50. doi: 10.1007/BF00311535.

DOI:10.1007/BF00311535
PMID:7640454
Abstract

This report describes the characterization of an estrogen receptor-positive breast cancer cell line, HMA-1, established from a breast cancer patient, based on the expression of tumor-associated antigens (TAAs), the HLA-DR antigen, and the c-erbB-2 proto-oncogene product. In flow cytometric and immunohistochemical analyses, HMA-1 was found to express increased levels of several TAAs including MUC1, TAG-72 (sialyl Tn), Tn, T, sialyl Le(a), Le(x), and Le(y). HMA-1 also expressed enhanced levels of the HLA-DR antigen and c-erbB-2 protein. These results indicate that HMA-1 is a unique cell line with abundant TAAs which may serve as an appropriate breast cancer cell line for application in the multidisciplinary research of breast cancer.

摘要

相似文献

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在人腺癌中积累的新型岩藻糖脂。III. 一种定义人癌相关二岩藻糖神经节苷脂（VI3NeuAcV3III3Fuc2nLc6）的杂交瘤抗体（FH6）。
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