Degawa H, Watanabe K, Beck Y, Tomikawa S, Nagao T, Uchida H
Department of Surgery and Transplantation, University of Tokyo, Japan.
Surg Today. 1995;25(5):474-6. doi: 10.1007/BF00311833.
The effect of the anti-cell adhesion molecule antibodies, anti-ICAM-1 (1A29) and anti-LFA-1 (WT1), on rat liver transplantation was investigated. Livers from ACI rats were transplanted into Lewis rats by Kamada's method and during the recipient operation 1A29 1 mg/kg, and WT1 1 mg/kg were administered intravenously to one group of rats (treated group). The survival time of the treated group was significantly longer than that of the untreated group, but permanent unresponsiveness could not be induced. Postmortem examination revealed little histological evidence of acute rejection in treated rats, in which the main cause of death was thought to be chronic rejection.
研究了抗细胞粘附分子抗体抗细胞间粘附分子-1（1A29）和抗淋巴细胞功能相关抗原-1（WT1）对大鼠肝移植的影响。采用Kamada法将ACI大鼠的肝脏移植到Lewis大鼠体内，在受体手术期间，给一组大鼠（治疗组）静脉注射1 mg/kg的1A29和1 mg/kg的WT1。治疗组的存活时间明显长于未治疗组，但未能诱导出永久性无反应状态。尸检显示，治疗大鼠的急性排斥反应的组织学证据很少，其主要死亡原因被认为是慢性排斥反应。
