Hurst L N, Gan B S
Department of Plastic Surgery, University Hospital, University of Western Ontario, London, Canada.
Br J Plast Surg. 1995 Jun;48(4):243-6. doi: 10.1016/0007-1226(95)90010-1.
Keratoacanthomas are rapidly growing benign cutaneous neoplasms, usually occurring on sun-exposed areas of the body. Although many treatment modalities have been described, surgical excision is currently the treatment of choice for the majority of keratoacanthomas. Occasionally, however, the size and location of these lesions preclude complete excision without extensive reconstruction and/or scarring. Two such cases of large keratoacanthoma of the nose were treated successfully with intralesional methotrexate. The rapid regression and very acceptable final cosmetic result suggest that intralesional methotrexate may play a beneficial role in the treatment of these difficult lesions and encourage further study of the benefits of this treatment modality.
角化棘皮瘤是迅速生长的良性皮肤肿瘤，通常发生于身体暴露于阳光的部位。尽管已有多种治疗方式被描述，但目前手术切除是大多数角化棘皮瘤的首选治疗方法。然而，这些病变的大小和位置偶尔会导致在不进行广泛重建和/或留疤的情况下无法完全切除。两例鼻部巨大角化棘皮瘤患者通过病灶内注射甲氨蝶呤成功治愈。其迅速消退以及非常令人满意的最终美容效果表明，病灶内注射甲氨蝶呤可能在这些难治性病变的治疗中发挥有益作用，并鼓励进一步研究这种治疗方式的益处。
