Ben-Bassat H, Vardi D V, Gazit A, Klaus S N, Chaouat M, Hartzstark Z, Levitzki A
Laboratory of Experimental Surgery, Hadassah University Hospital, Jerusalem, Israel.
Exp Dermatol. 1995 Apr;4(2):82-8. doi: 10.1111/j.1600-0625.1995.tb00227.x.
Tyrosine kinase inhibitors of the tyrphostin family which block EGF receptor kinase are reported to arrest the growth of psoriatic keratinocytes in vitro. Three tyrphostins with the potency ratio AG555 >> AG18 >> AG814 were found to arrest growth with no adverse cytotoxic effects. The potency ratio to inhibit keratinocyte proliferation follows their potency to inhibit EGF receptor kinase activity in vitro. These compounds represent novel leads for the therapy of psoriasis.
据报道，能阻断表皮生长因子（EGF）受体激酶的 tyrphostin 家族酪氨酸激酶抑制剂在体外可抑制银屑病角质形成细胞的生长。发现三种效力比为 AG555 >> AG18 >> AG814 的 tyrphostin 可抑制生长且无不良细胞毒性作用。抑制角质形成细胞增殖的效力比与其在体外抑制 EGF 受体激酶活性的效力一致。这些化合物是治疗银屑病的新型先导药物。
