Walter J S, McLane J, Cai W, Khan T, Cogan S
Hines VA Hospital, Rehabilitation Research and Development Center, IL 60141, USA.
J Spinal Cord Med. 1995 Jan;18(1):28-32. doi: 10.1080/10790268.1995.11719377.
This is a study of the reaction of large nerves to implantation using a flexible, thin-film cuff electrode. Cuff electrodes were implanted on the sciatic nerve of three cats. An implantation period of six weeks allowed sufficient time for any injury responses in the nerve and connective tissue sheath around the cuff to develop. The electrode came off the nerve in one of the cats. In the remaining two cats, gross observation following explantation of the electrodes revealed encapsulation of the cuffs without swelling of nerve tissue. Histological evaluation did not demonstrate nerve injury. The nerve cuff electrodes, which are comprised of titanium and iridium coatings on a fluorocarbon polymer substrate, appeared unaffected by the implantation, and connective tissue encapsulation did not adhere to either the polymer substrate or metallization. Evaluation of the electrodes using activated iridium oxide charge injection sites in more extended studies is now being undertaken.
这是一项关于使用柔性薄膜袖带电极植入大神经的反应的研究。将袖带电极植入三只猫的坐骨神经上。六周的植入期为神经和袖带周围结缔组织鞘中的任何损伤反应的发展留出了足够的时间。其中一只猫的电极从神经上脱落。在其余两只猫中，电极取出后的大体观察显示袖带被包裹，神经组织无肿胀。组织学评估未显示神经损伤。由氟碳聚合物基底上的钛和铱涂层组成的神经袖带电极似乎未受植入影响，结缔组织包裹未附着于聚合物基底或金属化层。目前正在进行更广泛研究中使用活性氧化铱电荷注入位点对电极的评估。
