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金属离子诱导的细胞膜通透性变化:一篇综述

Metal ion-induced permeability changes in cell membranes: a minireview.

作者信息

Kiss T, Osipenko O

机构信息

Balaton Limnological Research Institute, Hungarian Academy of Science, Tihany.

出版信息

Cell Mol Neurobiol. 1994 Dec;14(6):781-9. doi: 10.1007/BF02088684.

Abstract
  1. The paper summarizes the effects of the metal ions Cu2+, Pb2+, Ag+, Hg2+, Zn2+, and Cd2+ applied externally or internally to the surface membrane of different excitable cells. 2. Conductance changes induced by metal ions, and metal ion-activated current, are compared with respect to their ion and voltage dependence. 3. It is suggested that metal ion-induced effects can be realized through special structures of the cell membrane, the metal ion "receptors," although other mechanisms, as, for example, competition for Ca-binding sites in the channel forming proteins, cannot be excluded.
摘要
  1. 本文总结了外部或内部施加于不同可兴奋细胞膜表面的金属离子Cu2+、Pb2+、Ag+、Hg2+、Zn2+和Cd2+的作用。2. 比较了金属离子诱导的电导变化和金属离子激活电流在离子和电压依赖性方面的差异。3. 有人提出,金属离子诱导的效应可以通过细胞膜的特殊结构,即金属离子“受体”来实现,尽管不能排除其他机制,例如竞争通道形成蛋白中的钙结合位点。

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