Rice A S, Whitehead E M, O'Sullivan G, Lloyd J, Bullingham R E
Radcliffe Infirmary, Oxford, UK.
Eur J Anaesthesiol. 1995 May;12(3):313-7.
The speed of onset of analgesia following intravenous ketorolac, morphine and placebo was investigated in a single-dose, double-blind, randomized, parallel group study of 105 patients. The onset of analgesia was defined as the time at which the pain intensity score reached 50% of the baseline score in 25% of patients. Post-operative patients with moderate or severe pain were dosed and followed for 1 h. Pain reduction by at least 50% occurred in 25% of patients within 40 min (placebo), 15 min (morphine 5 mg), 6 min (morphine 10 mg) and 20 min (ketorolac 10 mg). The pain reduction time for morphine (10 mg) was significantly shorter than that for ketorolac (P = 0.01) or placebo (P < 0.01).
在一项针对105例患者的单剂量、双盲、随机、平行组研究中，研究了静脉注射酮咯酸、吗啡和安慰剂后镇痛起效的速度。镇痛起效被定义为25%的患者疼痛强度评分达到基线评分50%的时间。对中度或重度疼痛的术后患者给药并随访1小时。25%的患者在40分钟内（安慰剂组）、15分钟内（5毫克吗啡组）、6分钟内（10毫克吗啡组）和20分钟内（10毫克酮咯酸组）疼痛减轻至少50%。吗啡（10毫克）的疼痛减轻时间显著短于酮咯酸（P = 0.01）或安慰剂（P < 0.01）。
