Harter C
Institut für Biochemie I, Universität Heidelberg, Germany.
FEBS Lett. 1995 Aug 1;369(1):89-92. doi: 10.1016/0014-5793(95)00621-f.
COP-coated vesicles have originally been implicated in vesicular transport between subcompartments of the Golgi complex in mammals in a cis to trans direction. More recently, a role for COP-coated vesicles in transport between the endoplasmic reticulum (ER) and Golgi in mammalian cells has been proposed. Under certain conditions COP-coats have been localized to special domains of the transitional ER and to the cis side of the Golgi complex. This led to the assumption that COP-coated vesicles are involved in export of proteins from the ER. In addition, new findings point to a function of COP-coated vesicles in back transport of proteins from the Golgi to the ER. At present it is not known whether COP-coated vesicles move only in one or in both directions between ER and Golgi.
COP包被囊泡最初被认为参与哺乳动物高尔基复合体亚区室之间顺向到逆向的囊泡运输。最近，有人提出COP包被囊泡在哺乳动物细胞内质网（ER）和高尔基体之间的运输中发挥作用。在某些条件下，COP包被已定位到过渡性内质网的特殊区域以及高尔基体复合体的顺面。这导致人们推测COP包被囊泡参与蛋白质从内质网的输出。此外，新的研究结果表明COP包被囊泡在蛋白质从高尔基体逆向运输到内质网的过程中发挥作用。目前尚不清楚COP包被囊泡是否仅在内质网和高尔基体之间单向或双向移动。
