低剂量促性腺激素释放激素激动剂疗法在非黄体支持体外受精周期中的黄体期后果
Luteal phase consequences of low-dose gonadotropin-releasing hormone agonist therapy in nonluteal-supported in vitro fertilization cycles.
作者信息
Long C A, Sopelak V M, Lincoln S R, Cowan B D
机构信息
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216-4505, USA.
出版信息
Fertil Steril. 1995 Sep;64(3):573-6. doi: 10.1016/s0015-0282(16)57795-4.
OBJECTIVE
To determine the follicular and luteal phase impact of low-dose GnRH agonist (GnRH-a) treatment during follicular stimulation for IVF.
DESIGN
A randomized prospective study compared patients receiving low-dose GnRH-a and hMG therapy to clomiphene citrate (CC) and hMG cycles.
SETTING
Patients were treated through a university-based IVF-ET program.
PATIENTS
Thirty-six patients underwent follicular stimulation with low-dose GnRH-a and hMG and were compared with 34 patients undergoing ovulation induction with CC and hMG.
RESULTS
Significantly shorter luteal phase length occurred with GnRH-a and hMG therapy; however, there was no statistically significant difference in luteal P levels. Follicular parameters were the same (peak E2, number of follicles, and number of oocytes), suggesting that folliculogenesis was not altered. There were no statistical differences in pregnancy rates.
CONCLUSIONS
Sustained low-dose GnRH-a therapy during follicular stimulation does not have a clinical effect on luteal function.
目的
确定在体外受精（IVF）卵泡刺激过程中低剂量促性腺激素释放激素激动剂（GnRH-a）治疗对卵泡期和黄体期的影响。
设计
一项随机前瞻性研究，将接受低剂量GnRH-a和人绝经期促性腺激素（hMG）治疗的患者与接受枸橼酸氯米芬（CC）和hMG周期治疗的患者进行比较。
地点
患者通过一个大学附属医院的IVF-ET项目接受治疗。
患者
36例患者采用低剂量GnRH-a和hMG进行卵泡刺激，并与34例采用CC和hMG进行排卵诱导的患者进行比较。
结果
GnRH-a和hMG治疗组黄体期明显缩短；然而，黄体期孕酮（P）水平无统计学显著差异。卵泡参数相同（E2峰值、卵泡数量和卵母细胞数量），表明卵泡生成未改变。妊娠率无统计学差异。
结论
卵泡刺激期间持续低剂量GnRH-a治疗对黄体功能无临床影响。
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