Marshall J L, Andrews P A
Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, DC, USA.
Hematol Oncol Clin North Am. 1995 Apr;9(2):415-29.
Despite the general lack of clinical evidence supporting the preclinical data, there have been many attempts to overcome cisplatin resistance in clinical situations. These efforts have focused on both the proposed mechanisms of resistance as well as novel approaches to renew efficacy. In this article, the authors summarize the available clinical studies that have intentionally or serendipitously uncovered modulators of cisplatin sensitivity.
尽管普遍缺乏支持临床前数据的临床证据，但在临床情况下已有许多克服顺铂耐药性的尝试。这些努力既集中在提出的耐药机制上，也集中在恢复疗效的新方法上。在本文中，作者总结了有意或偶然发现的顺铂敏感性调节剂的现有临床研究。
