DNA的结构和热力学特性揭示了不同的进化历史。

Structural and thermodynamic properties of DNA uncover different evolutionary histories.

作者信息

Miramontes P, Medrano L, Cerpa C, Cedergren R, Ferbeyre G, Cocho G

机构信息

Département de Biochimie, Université de Montréal, Québec, Canada.

出版信息

J Mol Evol. 1995 Jun;40(6):698-704. doi: 10.1007/BF00160519.

DOI:10.1007/BF00160519

PMID:7643419

Abstract

We propose an index of DNA homogeneity (IDH) based on a binary distribution model that quantifies structural and thermodynamic aggregates present in DNA primary structures. Extensive analysis of sequence databases with the IDH uncovers significant constraints on DNA sequence other than those derived from codon usage or protein function. This index clearly distinguishes between organisms of different evolutive origins and places them in disjoint domains of DNA sequence space.

摘要

我们基于二元分布模型提出了一种DNA均一性指数（IDH），该模型可量化DNA一级结构中存在的结构和热力学聚集体。使用IDH对序列数据库进行的广泛分析揭示了DNA序列上除了源自密码子使用或蛋白质功能之外的显著限制。该指数能够清晰地区分不同进化起源的生物，并将它们置于DNA序列空间的不相交区域。