Papanikolaou N, Paliwal B
University of Wisconsin-Madison, Department of Medical Physics 53706, USA.
Med Phys. 1995 May;22(5):571-5. doi: 10.1118/1.597584.
The primary goal of intraoperative radiation therapy is to irradiate the intraoperatively determined tumor target volume with a single fraction of tumoroidal dose while minimizing the dose to all adjacent healthy tissues. To reduce dose outside the treatment volume, lead sheets are often used to cover the external surface of the cone tip thus providing a shielding for the tissues outside the field. In this paper, the effect of the shielding on the depth dose distributions and dose profiles at different depths is studied based on experimental data. The results were also compared against an EGS4 Monte Carlo code for the same geometry as the measurements. The cones varied in size having diameters of 5 cm, 7 cm, and 9 cm, and the electron energies ranged from 6 MeV to 22 MeV. The depth dose curves and dose profiles (at two different depths in the phantom) were measured and computed with and without the lead shielding for the various combinations of cone sizes and electron energies using a water phantom to simulate the patient. It was found that the presence of lead increases on average across the treatment area the dose to the tumor from 2% up to 5%, while the dose outside the cone was reduced by as much as 75%. Both measurements and calculations were found to be in agreement.
术中放射治疗的主要目标是,用单次肿瘤剂量照射术中确定的肿瘤靶区,同时尽量减少对所有相邻健康组织的剂量。为了减少治疗体积外的剂量,通常使用铅板覆盖锥形尖端的外表面,从而为射野外的组织提供屏蔽。在本文中,基于实验数据研究了这种屏蔽对不同深度处的深度剂量分布和剂量剖面的影响。还将结果与针对与测量相同几何形状的EGS4蒙特卡罗代码进行了比较。锥形尺寸各异,直径分别为5厘米、7厘米和9厘米,电子能量范围为6兆电子伏至22兆电子伏。使用水模模拟患者,针对锥形尺寸和电子能量的各种组合,在有和没有铅屏蔽的情况下测量并计算了深度剂量曲线和剂量剖面(在模体中的两个不同深度处)。结果发现,铅的存在使整个治疗区域内肿瘤的剂量平均从2%增加到5%,而锥形外的剂量减少了多达75%。测量和计算结果一致。