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Heterogeneity of GABAA-receptors: cell-specific expression, pharmacology, and regulation.

作者信息

Mohler H, Knoflach F, Paysan J, Motejlek K, Benke D, Lüscher B, Fritschy J M

机构信息

Institute of Pharmacology, University, Zürich, Switzerland.

出版信息

Neurochem Res. 1995 May;20(5):631-6. doi: 10.1007/BF01694546.

DOI:10.1007/BF01694546
PMID:7643969
Abstract

Vigilance, anxiety, memory, epileptogenic activity and muscle tension can be regulated by a modulation of GABAA-receptor function. A multitude of different GABAA-receptors exist in the brain due to the combinational assembly of various subunits encoded by at least 15 genes. The clarification of the physiological and pharmacological significance of GABAA-receptor subtypes, in combination with their cellular localization, will make it possible to identify the neuronal circuits regulating the respective CNS states and to provide strategies for the development of subtype-specific drugs for selective therapies.

摘要

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本文引用的文献

1
Neuron-specific expression of GABAA-receptor subtypes: differential association of the alpha 1- and alpha 3-subunits with serotonergic and GABAergic neurons.
Neuroscience. 1993 Jun;54(4):881-92. doi: 10.1016/0306-4522(93)90582-z.
2
Full and partial agonism displayed by benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.苯二氮䓬受体配体在重组γ-氨基丁酸A受体亚型上表现出的完全激动和部分激动作用。
J Pharmacol Exp Ther. 1993 Jul;266(1):385-91.
3
GABAA-receptors: drug binding profile and distribution of receptors containing the alpha 2-subunit in situ.
J Recept Res. 1993;13(1-4):467-77. doi: 10.3109/10799899309073673.
4
Pin1 依赖性信号传导通过调节神经连接蛋白 2/gephyrin 相互作用对 γ-氨基丁酸能传递产生负面影响。
Nat Commun. 2014 Oct 9;5:5066. doi: 10.1038/ncomms6066.
4
Long-term behavioral programming induced by peripuberty stress in rats is accompanied by GABAergic-related alterations in the Amygdala.青春期应激诱导的大鼠长期行为编程伴随着杏仁核中与γ-氨基丁酸能相关的改变。
PLoS One. 2014 Apr 15;9(4):e94666. doi: 10.1371/journal.pone.0094666. eCollection 2014.
5
Inhibitory plasticity dictates the sign of plasticity at excitatory synapses.抑制性可塑性决定了兴奋性突触的可塑性的符号。
J Neurosci. 2014 Jan 22;34(4):1083-93. doi: 10.1523/JNEUROSCI.4711-13.2014.
6
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Mol Neurobiol. 2011 Aug;44(1):28-52. doi: 10.1007/s12035-011-8185-1. Epub 2011 May 6.
7
The short splice variant of the gamma 2 subunit acts as an external modulator of GABA(A) receptor function.γ2 亚基的短剪接变体充当 GABA(A) 受体功能的外部调节剂。
J Neurosci. 2010 Apr 7;30(14):4895-903. doi: 10.1523/JNEUROSCI.5039-09.2010.
8
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Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.苯二氮䓬受体配体在重组γ-氨基丁酸A受体亚型上的亲和力和效力差异。
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J Neurosci. 1994 Apr;14(4):2236-59. doi: 10.1523/JNEUROSCI.14-04-02236.1994.
9
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10
Biphasic differential changes of GABAA receptor subunit mRNA levels in dentate gyrus granule cells following recurrent kindling-induced seizures.复发性点燃诱导癫痫发作后齿状回颗粒细胞中GABAA受体亚基mRNA水平的双相差异变化。
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