晚期帕金森病患者的苍白球腹后内侧切开术
Ventroposterior medial pallidotomy in patients with advanced Parkinson's disease.
作者信息
Sutton J P, Couldwell W, Lew M F, Mallory L, Grafton S, DeGiorgio C, Welsh M, Apuzzo M L, Ahmadi J, Waters C H
机构信息
Department of Neurology, University of Southern California Medical School, Los Angeles, USA.
出版信息
Neurosurgery. 1995 Jun;36(6):1112-6; discussion 1116-7. doi: 10.1227/00006123-199506000-00007.
In a preliminary study, the effects of ventroposterior medial pallidotomy were evaluated in five patients with advanced Parkinson's disease in whom medical therapy had failed. The mean age was 67.0 +/- 5.6 years, and the mean Hoehn and Yahr stage when "off" was 3.9 +/- 1.3. Three patients received unilateral pallidotomies; two of these received another pallidotomy after 8 weeks. Two other patients received staged bilateral pallidotomies. No significant differences in overall function could be seen before and after the first surgical procedure. All three patients with peak-dose dyskinesias or dystonia had marked contralateral reduction in these symptoms. Ventroposterior medial pallidotomy can ameliorate peak-dose dyskinesias in patients with advanced Parkinson's disease. Overall function improvement is not remarkable.
在一项初步研究中，对5例药物治疗无效的晚期帕金森病患者进行了腹后内侧苍白球切开术的疗效评估。平均年龄为67.0±5.6岁，“关”期时Hoehn和Yahr平均分期为3.9±1.3。3例患者接受了单侧苍白球切开术；其中2例在8周后接受了另一次苍白球切开术。另外2例患者接受了分期双侧苍白球切开术。首次手术前后整体功能无显著差异。所有3例有峰剂量异动症或肌张力障碍的患者这些症状均有明显的对侧减轻。腹后内侧苍白球切开术可改善晚期帕金森病患者的峰剂量异动症。整体功能改善不显著。
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