非甾体抗炎药会降低患阿尔茨海默病的风险吗？鹿特丹研究。

Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease? The Rotterdam Study.

作者信息

Andersen K, Launer L J, Ott A, Hoes A W, Breteler M M, Hofman A

机构信息

Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.

出版信息

Neurology. 1995 Aug;45(8):1441-5. doi: 10.1212/wnl.45.8.1441.

DOI:10.1212/wnl.45.8.1441

PMID:7644037

Abstract

Based on reports that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the risk for Alzheimer's disease (AD), we studied the cross-sectional relation between NSAID use and the risk for AD in a population-based study of disease and disability in older people. After controlling for age, education, gender, and use of benzodiazepines, we found a relative risk (RR) for AD of 0.38 (0.15 to 0.95) when comparing NSAID users (n = 365) to NSAID non-users (n = 5,893). To address confounding by indication or contraindication, we compared NSAID users with a subset of NSAID non-users who were using topical medication for ear, eye, or dermatologic conditions (n = 365). In this comparison, the adjusted RR for AD was 0.54 (0.16 to 1.78). These findings are compatible with a possible protective effect of NSAIDs on the risk for AD.

摘要

基于非甾体抗炎药（NSAIDs）的使用可能降低阿尔茨海默病（AD）风险的报道，我们在一项针对老年人疾病与残疾的基于人群的研究中，研究了NSAIDs使用与AD风险之间的横断面关系。在控制了年龄、教育程度、性别和苯二氮䓬类药物的使用情况后，将NSAIDs使用者（n = 365）与非使用者（n = 5,893）进行比较时，我们发现AD的相对风险（RR）为0.38（0.15至0.95）。为了解决因适应症或禁忌症导致的混杂问题，我们将NSAIDs使用者与一部分使用耳部、眼部或皮肤病局部用药的非NSAIDs使用者（n = 365）进行了比较。在该比较中，AD的校正RR为0.54（0.16至1.78）。这些发现与NSAIDs对AD风险可能具有保护作用相符。