René P C, Oliva V L, Bui B T, Froment D, Harel C, Nicolet V, Courteau M, Carignan L
Department of Radiology, Hôpital Notre-Dame, Montreal, Quebec, Canada.
Radiology. 1995 Sep;196(3):675-9. doi: 10.1148/radiology.196.3.7644628.
To evaluate the modifications of Doppler ultrasound waveform morphology after inhibition of angiotensin-converting enzyme with captopril to increase the sensitivity of Doppler sonography in detecting renal artery stenosis.
Sixty-two renal arteries were studied in 31 hypertensive patients who underwent Doppler scanning before and 1 hour after administration of captopril prior to undergoing angiography. Pattern recognition criteria were applied to classify the Doppler waveforms as having a normal or pulsus tardus configuration. Doppler scanning results were compared with those of arteriography.
On the basis of recognition of the pulsus tardus, precaptopril Doppler scanning showed 13 (68%) of 19 significant renal artery stenoses found at angiography (95% confidence interval, 0.43, 0.85), whereas 19 (100%) of 19 stenoses were detected with postcaptopril Doppler scanning (95% confidence interval, 0.85, 1.0).
Captopril significantly (95% confidence intervals) increases Doppler scanning sensitivity in detecting renal artery stenoses by inducing or enhancing the pulsus tardus distal to a significant renal artery stenosis.
评估使用卡托普利抑制血管紧张素转换酶后多普勒超声波形形态的改变，以提高多普勒超声检查在检测肾动脉狭窄方面的敏感性。
对31例高血压患者的62条肾动脉进行研究，这些患者在进行血管造影之前，分别于服用卡托普利前及服药后1小时接受多普勒扫描。应用模式识别标准将多普勒波形分类为具有正常或迟脉配置。将多普勒扫描结果与动脉造影结果进行比较。
基于迟脉的识别，服用卡托普利前的多普勒扫描显示，血管造影发现的19处显著肾动脉狭窄中有13处（68%）被检测到（95%置信区间，0.43，0.85），而服用卡托普利后的多普勒扫描检测到了19处狭窄中的19处（100%）（95%置信区间，0.85，1.0）。
卡托普利通过诱导或增强显著肾动脉狭窄远端的迟脉，显著（95%置信区间）提高了多普勒扫描检测肾动脉狭窄的敏感性。
