Brandtzaeg P, Fausa O
Laboratorium for Immunhistokjemi og immunopatologi Institutt/avdeling for patologi, Universitetet i Oslo Rikshospitalet.
Tidsskr Nor Laegeforen. 1995 Jun 30;115(17):2067-71.
Norwegian immunological research in gastroenterology is well recognized internationally, and the European Medical Research Council Clinical Network for Gastroenterological Immunology is organized from Oslo. This development can be explained mainly by successful cooperation between clinical gastroenterology and laboratory-based research. A current jubilee in each of these fields may justify this review. It is now well documented that the gut is the largest antibody-producing organ. A unique molecular integration exists between the local B cells and the secretory epithelium to facilitate external transport of dimeric IgA and pentameric IgM. The mucosal immune system is subjected to T-cell regulation and significant local alterations are observed in T- and B-cell populations, and in the macrophage subsets associated with several diseases of the gut. Subsequent functional immune deviation may largely explain mucosal pathology and indicates potential targets for future immunotherapeutic measures. Observations made in the gut mucosa of HIV/AIDS patients have contributed to greater understanding of the complex cellular and molecular interactions involved in mucosal immunity.
挪威在胃肠病学方面的免疫学研究在国际上得到了广泛认可，欧洲医学研究理事会胃肠病学免疫学临床网络也以奥斯陆为中心进行组织。这一发展主要得益于临床胃肠病学与实验室研究之间的成功合作。这两个领域当前的周年纪念或许为本次综述提供了契机。如今已有充分证据表明，肠道是最大的抗体产生器官。局部B细胞与分泌上皮细胞之间存在独特的分子整合，以促进二聚体IgA和五聚体IgM的向外转运。黏膜免疫系统受T细胞调节，在T细胞和B细胞群体以及与多种肠道疾病相关的巨噬细胞亚群中观察到显著的局部变化。随后发生的功能性免疫偏差在很大程度上可以解释黏膜病理学现象，并为未来的免疫治疗措施指明了潜在靶点。对HIV/AIDS患者肠道黏膜的观察有助于更深入地理解黏膜免疫中复杂的细胞和分子相互作用。
