Khayyal M T, Tolba H, El-Hawary M B
J Pharm Pharmacol. 1976 Jun;28(6):489-92. doi: 10.1111/j.2042-7158.1976.tb02771.x.
The rabbit stomach serosal strip, was found to contract to adrenaline and noradrenaline but not to isoprenaline. The contractile response could be totally abolished by phenoxybenzamine but was not influenced by propranolol, indicating that the preparation has almost exclusively alpha-adrenoceptors. The responses to adrenaline and noradrenaline were markedly potentiated in the presence of monoamine oxidase inhibitors, guanethidine or reserpine, indicating the presence of MAO activity in the tissue and possible catecholamine stores. The functional state of the latter has not been conclusively established, since tyramine, an indirectly acting amine, was unable to elicit a response qualitatively similar to that of adrenaline, even in the presence of nialamide or tranylcypromine.
发现兔胃浆膜条对肾上腺素和去甲肾上腺素产生收缩反应，但对异丙肾上腺素无反应。苯氧苄胺可完全消除其收缩反应，但普萘洛尔对其无影响，这表明该制剂几乎只存在α -肾上腺素能受体。在单胺氧化酶抑制剂、胍乙啶或利血平存在的情况下，对肾上腺素和去甲肾上腺素的反应明显增强，这表明组织中存在单胺氧化酶活性以及可能的儿茶酚胺储存。后者的功能状态尚未最终确定，因为即使在烟肼酰胺或反苯环丙胺存在的情况下，间接作用胺酪胺也无法引发与肾上腺素定性相似的反应。
