Rasmussen P E
Odense Universitetshospital, gynaekologisk-obstetrisk afdeling D, fertilitetsklinikken.
Ugeskr Laeger. 1995 Jul 31;157(31):4346-9.
A prospective study of 48 cases of microsurgery for infertility caused by tubal occlusion carried out at Odense University Hospital during the years 1989-92 is presented. The follow-up period was between one to five years. The overall term pregnancy rate was 25% and the ectopic pregnancy rate 19%. Based on a simple peroperative scoring system all patients could be allocated to two clearly separated prognostic categories with term pregnancy rates of 42% and 15% and ectopic pregnancy rates of 14% and 21% respectively. In accordance with other recent studies, this study showed that acceptable term pregnancy rates, i.e., about 40-50%, were achieved by salpingolysis and fimbrioplasty/salpingostomy only in cases where the adhesions were few, the tubal wall normal or thin and the endosalpinx appeared macroscopically normal. In cases of medial stenosis/occlusions, irrespective of the occurrence of lateral tubal damage, the results are poor. The only exception to this is reversal of sterilisation. Today the cumulated term pregnancy rate after three IVF-attempts in the same group of patients is about 55-60%. If microsurgical infertility treatment is to be considered an option, it is imperative that the success rate is comparable to that of the IVF success rate. This is only to be expected with stringent preoperative selection using a simple scoring system. It is concluded that microsurgical and certainly macrosurgical treatment of infertility should be abandoned in the vast majority of cases.
本文介绍了1989年至1992年在欧登塞大学医院对48例因输卵管阻塞导致不孕的患者进行显微手术的前瞻性研究。随访期为1至5年。总体足月妊娠率为25%,异位妊娠率为19%。基于一个简单的术中评分系统,所有患者可被分为两个明显不同的预后类别,足月妊娠率分别为42%和15%,异位妊娠率分别为14%和21%。与其他近期研究一致,本研究表明,仅在粘连少、输卵管壁正常或薄且输卵管内膜肉眼观正常的情况下,通过输卵管粘连松解术和输卵管造口术/输卵管吻合术可获得可接受的足月妊娠率,即约40%至50%。在内侧狭窄/阻塞的情况下,无论输卵管外侧是否受损,结果都很差。唯一的例外是输卵管绝育术的逆转。如今,同一组患者在进行三次体外受精尝试后的累积足月妊娠率约为55%至60%。如果要将显微手术不孕治疗视为一种选择,那么成功率必须与体外受精成功率相当。只有通过使用简单的评分系统进行严格的术前选择才能实现这一点。结论是,在绝大多数情况下,应放弃对不孕的显微手术治疗,当然也应放弃宏观手术治疗。