Winters J C, Appell R
Department of Urology, Cleveland Clinic Foundation, Ohio, USA.
Urol Clin North Am. 1995 Aug;22(3):673-8.
In properly selected patients, the periurethral injection of collagen is a safe and effective form of management for females with intrinsic sphincteric dysfunction. Performed under local anesthesia, this procedure allows for the treatment of patients who may not be suitable candidates for anesthesia and formal surgery. In female patients, excellent treatment results are obtained, which appear durable for greater than 2 years; these results are obtained usually within three treatment sessions. Periurethral collagen injection has been shown to elicit only a minimal inflammatory reaction and there have been no adverse immunogenic effects, foreign-body reaction, or migration of the injected material. Adverse events associated with the periurethral injection of collagen are rare. Collagen has proven to be a highly efficacious substance for use in periurethral injections for the treatment of intrinsic sphincteric dysfunction.
对于经过恰当筛选的患者，尿道周围注射胶原蛋白是治疗女性真性压力性尿失禁的一种安全有效的方法。该操作在局部麻醉下进行，适用于那些可能不适合全身麻醉和正规手术的患者。在女性患者中，治疗效果良好，且可持续两年以上；通常在三次治疗疗程内即可取得这些效果。尿道周围注射胶原蛋白仅引起轻微的炎症反应，未出现不良免疫原性效应、异物反应或注射材料移位。与尿道周围注射胶原蛋白相关的不良事件很少见。胶原蛋白已被证明是用于尿道周围注射治疗真性压力性尿失禁的一种高效物质。
