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某些5-羟色胺受体亚型的激动剂和拮抗剂对记忆的影响及其受5-羟色胺摄取抑制剂氟西汀的调节作用。

Effects of agonists and antagonists of some serotonin-receptor subtypes on memory and their modulation by the 5-HT-uptake inhibitor fluoxetine.

作者信息

Petkov V D, Kehayov R

机构信息

Institute of Physiology, Bulgarian Academy of Sciences, Sofia.

出版信息

Acta Physiol Pharmacol Bulg. 1994;20(3-4):83-90.

PMID:7645408
Abstract

The memory effects of agonists and antagonists of some serotonin (5-HT)-receptor subtypes were studied in experiments on rats using the method for passive avoidance with punishment reinforcement (step-down). The 5-HT1A-receptor agonist buspirone (1 mg/kg i.p.) elicited behavioural responses which suggested the lack of pronounced effect on learning and retention; the 5-HT1A-receptor antagonists NAN-190 (1 mg/kg i.p.) and pindolol (6 mg/kg i.p.) impaired retention tested 24 hours and 7 days after training as compared to controls. The 5-HT2-receptor antagonist ritanserin (1 mg/kg i.p.) impaired retention tested 24 hours and 7 days after training as compared to controls, while the 5-HT3-receptor antagonist ondansetron (0.1 mg/kg i.p.) improved it. The 5-HT1/5-HT2-receptor antagonist dotarizine (50 mg/kg orally), characterized by a calcium-antagonistic action, too, exerted some facilitating effect on learning. Most of the effects of the 5-HT-receptor agonists and antagonists were changed when the 5-HT concentration in the synaptic region was increased by the 5-HT-uptake inhibitor fluoxetine (20 mg/kg orally). The results suggest different participation of 5-HT1A-, 5-HT2- and 5-HT3-receptors in the mechanisms of memory process and its modulation by the serotonin level in the cerebral serotonergic synapses.

摘要

在大鼠实验中,采用带有惩罚强化的被动回避(台阶式下降)方法,研究了某些5-羟色胺(5-HT)受体亚型激动剂和拮抗剂的记忆效应。5-HT1A受体激动剂丁螺环酮(腹腔注射1mg/kg)引发的行为反应表明其对学习和记忆保持没有明显影响;与对照组相比,5-HT1A受体拮抗剂NAN-190(腹腔注射1mg/kg)和吲哚洛尔(腹腔注射6mg/kg)在训练后24小时和7天测试时损害了记忆保持。5-HT2受体拮抗剂利坦色林(腹腔注射1mg/kg)与对照组相比,在训练后24小时和7天测试时损害了记忆保持,而5-HT3受体拮抗剂昂丹司琼(腹腔注射0.1mg/kg)则改善了记忆保持。兼具钙拮抗作用的5-HT1/5-HT2受体拮抗剂多他利嗪(口服50mg/kg)对学习也有一定促进作用。当5-HT摄取抑制剂氟西汀(口服20mg/kg)使突触区域的5-HT浓度增加时,5-HT受体激动剂和拮抗剂的大多数效应发生了改变。结果表明,5-HT1A、5-HT2和5-HT3受体在记忆过程机制及其受脑内5-羟色胺能突触中5-羟色胺水平调节方面有不同程度的参与。

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