Wolf C, Wallnöfer A, Waldhör T, Vutuc C, Meisinger V, Rüdiger H W
Department of Occupational Medicine, University Clinic of Internal Medicine IV, Vienna, Austria.
Am J Ind Med. 1995 Jun;27(6):897-903. doi: 10.1002/ajim.4700270613.
To determine if low-level exposure to lead has an effect on arterial blood pressure, demographic and clinical data of a group of 507 males without any occupational exposure to lead were analyzed in a retrospective study. The following variables were included in the analysis: age, height, weight, nicotine consumption, alcohol intake, blood lead, systolic blood pressure, diastolic blood pressure, and erythrocyte count. The effects of the variables age, weight, height, alcohol intake, nicotine consumption, and blood lead on blood pressure were investigated by stepwise linear regression analysis. The diastolic as well as the systolic blood pressure was significantly influenced by Body Mass Index, age, and alcohol. A significant effect of lead could be found only for diastolic blood pressure. None of the possible interactions were significant enough to merit inclusion in the statistical model. Regarding the strength of the effects on diastolic blood pressure we find that lead ranks after age, weight. In conclusion, this study shows that lead has an effect on diastolic arterial blood pressure in a survey of a group of middle-aged, occupationally nonexposed men.
为了确定低水平铅暴露是否会对动脉血压产生影响，在一项回顾性研究中，对一组507名无任何职业性铅暴露的男性的人口统计学和临床数据进行了分析。分析中纳入了以下变量：年龄、身高、体重、尼古丁摄入量、酒精摄入量、血铅水平、收缩压、舒张压和红细胞计数。通过逐步线性回归分析研究了年龄、体重、身高、酒精摄入量、尼古丁摄入量和血铅水平这些变量对血压的影响。舒张压和收缩压均受到体重指数、年龄和酒精的显著影响。仅在舒张压方面发现铅有显著影响。所有可能的相互作用均未显著到足以纳入统计模型。关于对舒张压影响的强度，我们发现铅的影响排在年龄、体重之后。总之，本研究表明，在对一组中年、无职业暴露男性的调查中，铅会对舒张期动脉血压产生影响。
