Quaid K A, Wesson M K
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202-5251, USA.
Am J Med Genet. 1995 May 22;57(1):46-51. doi: 10.1002/ajmg.1320570111.
The focus in predictive testing for Huntington disease is beginning to shift from individuals at risk to an examination of the effects on other relatives, particularly on spouses and partners. We examine the effects of participating in a predictive testing program for 25 couples. When assessed prior to testing, spouses were significantly more depressed than their at-risk partners. After pretest counseling, 6 (24%) of the couples chose not to pursue testing. At baseline, these 6 couples had significantly higher levels of psychological distress and marital dysfunction than couples who did choose to complete testing. Of the 19 couples completing testing, 5 received an increased risk result and 14 received a decreased risk result. Prior to testing, the partners of individuals who later received an increased risk result exhibited higher levels of marital distress. At 3- and 6-month follow-ups, high-risk couples were significantly more distressed than low-risk couples. These levels of distress improved somewhat at 9 months after testing, but began to climb again at 12 months. Individuals at increased risk were significantly more distressed at all points during follow-up as compared to individuals at low risk. No significant differences were found between the partners of high- and low-risk individuals at 3, 6, 9, and 12 months after disclosure.(ABSTRACT TRUNCATED AT 250 WORDS)
亨廷顿病预测性检测的重点开始从有风险的个体转向研究对其他亲属的影响，尤其是对配偶和伴侣的影响。我们研究了参与预测性检测项目的25对夫妇的情况。在检测前进行评估时，配偶的抑郁程度明显高于有风险的伴侣。经过检测前咨询，6对（24%）夫妇选择不进行检测。在基线时，这6对夫妇的心理困扰和婚姻功能障碍水平明显高于选择完成检测的夫妇。在完成检测的19对夫妇中，5对得到风险增加的结果，14对得到风险降低的结果。在检测前，后来得到风险增加结果的个体的伴侣表现出更高的婚姻困扰水平。在3个月和6个月的随访中，高风险夫妇的困扰程度明显高于低风险夫妇。检测后9个月时，这些困扰程度有所改善，但在12个月时又开始上升。与低风险个体相比，高风险个体在随访期间的所有时间点困扰程度都明显更高。在结果披露后的3个月、6个月、9个月和12个月，高风险和低风险个体的伴侣之间未发现显著差异。（摘要截短于250字）
