Ludewig T, Gutte G, Zimmermann H
Veterinär-Anatomisches Institut, Veterinärmedizineischen Fakultät, Universität Leipzig, Deutschland.
Anat Histol Embryol. 1995 Mar;24(1):7-12. doi: 10.1111/j.1439-0264.1995.tb00002.x.
The antispermatongenic effects of furazolidone on the testes of mature Wistar rats were investigated using histological and morphometric methods. The sections showed a varying degree of depopulation of the germinal epithelium, a shrinking and a deformation of the Tubuli contorti, and an enlargement of the intertubular lymphatic sinuses. The strain led to a standstill in the spermatogenesis at the primary-spermatocyte stage. After administering furazolidone, the following results could be seen: a weight loss of up to 42.1% and a decrease in testes volume by up to 30.2%; a decrease in the volume of the nuclei of the Leydig-cells by up to 51.6%; a reduction in the diameter, perimeter and area covered by Tubuli seminiferi contorti of up to 33.5%, 30.8%, and 53.4%, respectively; an increase in the number of Tubuli seminiferi contorti per mm2 by up to 44.8%; a decrease in the percentage of Tubuli seminiferi contorti of the total testes tissue by up to 39.1%.
采用组织学和形态计量学方法，研究了呋喃唑酮对成熟Wistar大鼠睾丸的抗生精作用。切片显示生精上皮细胞有不同程度的减少，曲细精管萎缩变形，管间淋巴窦扩大。该菌株导致精子发生在初级精母细胞阶段停滞。给予呋喃唑酮后，可观察到以下结果：体重减轻高达42.1%，睾丸体积减少高达30.2%；睾丸间质细胞的细胞核体积减少高达51.6%；曲细精管的直径、周长和覆盖面积分别减少高达33.5%、30.8%和53.4%；每平方毫米曲细精管数量增加高达44.8%；曲细精管占总睾丸组织的百分比减少高达39.1%。
