Suppr超能文献

[缺血预处理:内源性心肌保护的概念]

[Ischemic preconditioning: concept of endogenous myocardial protection].

作者信息

Ovize M, Henry P, Rioufol G, Minaire Y, André-Fouët X, Escande D

机构信息

Hôpital cardiologique et pneumologique Louis-Pradel, Lyon.

出版信息

Arch Mal Coeur Vaiss. 1995 Jun;88(6):869-77.

PMID:7646301
Abstract

Preconditioning is a temporary tolerance to ischaemia acquired by the myocardium after a short period of ischaemia. It results in the limitation of the infarct size induced by prolonged coronary occlusion. The mechanism of this cytoprotection remains poorly understood. The A1 adenosine receptors, the ATP-sensitive potassium channels and protein-kinase C seem to play prominent roles. The effects of preconditioning on the complications of ischaemia/reperfusion such as myocardial stunning, ventricular arrhythmias or decreased coronary reserve are not well known. Several studies suggest that the cytoprotection resulting from preconditioning could be applied to human myocardium and constitute a preventive anti-ischaemic therapy during coronary angioplasty, cardiac surgery or the conservation of transplant grafts.

摘要

预处理是心肌在经历短时间缺血后获得的对缺血的一种暂时耐受性。它可限制因冠状动脉长时间阻塞所诱发的梗死面积。这种细胞保护作用的机制仍知之甚少。A1腺苷受体、ATP敏感性钾通道及蛋白激酶C似乎发挥着重要作用。预处理对缺血/再灌注并发症(如心肌顿抑、室性心律失常或冠状动脉储备降低)的影响尚不明确。多项研究表明,预处理产生的细胞保护作用可应用于人类心肌,并可在冠状动脉血管成形术、心脏手术或移植移植物保存期间构成一种预防性抗缺血治疗方法。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验