Schneider T, Reiter C, Eule E, Bader B, Lichte B, Nie Z, Schimansky T, Ramos R G, Fischbach K F
Institut für Biologie III, Albert-Ludwigs-Universität Freiburg, Germany.
Neuron. 1995 Aug;15(2):259-71. doi: 10.1016/0896-6273(95)90032-2.
The 104 kDa irreC-rst protein, a member of the immunoglobulin superfamily, mediates homophilic adhesion in cell cultures. In larval optic chiasms, the protein is found on recently formed axon bundles, not on older ones. In developing visual neuropils, it is present in all columnar domains of specific layers. The number of irreC-rst-positive neuropil stratifications increases until the midpupal stage. Immunoreactivity fades thereafter. The functional importance of the restricted expression pattern is demonstrated by the severe projection errors of axons in the first and second optic chiasms in loss of function mutants and in transformants that express the irreC-rst protein globally. Epigenesis of the phenotypes can be explained partially on the bases of homophilic irreC-rst interactions.
104 kDa的irreC-rst蛋白是免疫球蛋白超家族的成员，在细胞培养中介导同嗜性黏附。在幼虫视交叉中，该蛋白存在于最近形成的轴突束上，而非较老的轴突束。在发育中的视觉神经纤维网中，它存在于特定层的所有柱状区域。直到蛹中期，irreC-rst阳性神经纤维网分层的数量都会增加。此后免疫反应性逐渐消失。功能丧失突变体以及全局表达irreC-rst蛋白的转化体中，第一和第二视交叉处轴突的严重投射错误证明了这种受限表达模式的功能重要性。表型的后生现象可以部分基于同嗜性irreC-rst相互作用来解释。
