van Golde L M
Department of Veterinary Basic Sciences, Utrecht University, The Netherlands.
Biol Neonate. 1995;67 Suppl 1:2-17. doi: 10.1159/000244202.
The physiological role of pulmonary surfactant is probably not limited to conferring mechanical stability to the alveoli. Increasing evidence suggests that surfactant components, in particular the hydrophilic surfactant proteins SP-A and SP-D, play potentially important roles in host defense mechanisms. Both SP-A and SP-D are collagenous C-type lectins (collectins) that are structurally and, perhaps, functionally related to collectins in the circulation. As will be discussed in this review, evidence is accumulating that the alveolar collectins SP-A and SP-D could be important components of a first-line defense system against infiltrating pathogenic micro-organisms and viruses.
肺表面活性物质的生理作用可能不仅限于赋予肺泡机械稳定性。越来越多的证据表明，表面活性物质成分，特别是亲水性表面活性蛋白SP-A和SP-D，在宿主防御机制中发挥着潜在的重要作用。SP-A和SP-D都是胶原性C型凝集素（collectins），它们在结构上，或许在功能上，与循环中的凝集素相关。正如本综述将要讨论的，越来越多的证据表明，肺泡凝集素SP-A和SP-D可能是抵御入侵病原微生物和病毒的一线防御系统的重要组成部分。
