Yan Y, Ran X, Wei S
Department of Radiation Medicine, Third Military Medical College, Chongqing.
Chin Med Sci J. 1995 Jun;10(2):85-9.
The changes of several immune functions were observed in rats after they were inflicted with 6 Gy gamma rays irradiation, 15% TBSA full thickness brun and the combination of the 2 injuries. It was found that the functions of thymocytes and splenoctyes suffered the most severe suppression in the 24th to 72nd hour after radiation injury and began to recover on the 7th day. In the rats with burn injury, the suppression on thymocytes and splenocytes were significantly less severe than that after radiation and recovered more rapidly. The effects of combined radiation-burn injury showed several characteristics. The suppression on the thymocytes was more severe with slower recovery as compared with that after single radiation injury only. The suppression on the splenocytes as a whole was similar to that after single radiation injury, but in the early stage after combined injury, the suppression was far more severe than that after radiation. Escharectomy and skin grafting on the burn wounds on the 1st day after combined injury could accelerate the recovery on both the thymocytes and splenocytes. Our findings indicated that the severity of the suppression on the immune functions due to combined radiation-burn injury might depend on the size of the burn wounds.
观察6 Gy γ射线照射、15%体表面积全层烧伤以及两种损伤联合作用后大鼠的几种免疫功能变化。发现辐射损伤后24至72小时，胸腺细胞和脾细胞功能受到最严重抑制，并在第7天开始恢复。在烧伤大鼠中，对胸腺细胞和脾细胞的抑制明显轻于辐射后，且恢复更快。辐射烧伤联合损伤的影响呈现出几个特点。与仅单次辐射损伤相比，对胸腺细胞的抑制更严重，恢复更慢。总体上对脾细胞的抑制与单次辐射损伤后相似，但在联合损伤后的早期阶段，抑制远比辐射后严重。联合损伤后第1天对烧伤创面行焦痂切除和皮肤移植可加速胸腺细胞和脾细胞的恢复。我们的研究结果表明，辐射烧伤联合损伤对免疫功能抑制的严重程度可能取决于烧伤创面的大小。
