第三次使用甲巯咪唑治疗后的胰岛素自身免疫综合征。

Insulin autoimmune syndrome after the third therapy with methimazole.

作者信息

Hakamata M, Itoh M, Sudo Y, Miyata N

机构信息

Department of Internal Medicine, Enshu General Hospital, Hamamatsu.

出版信息

Intern Med. 1995 May;34(5):410-2. doi: 10.2169/internalmedicine.34.410.

DOI:10.2169/internalmedicine.34.410

PMID:7647412

Abstract

In 1986, a 26-year-old female had been diagnosed as having Graves' disease and had been treated with methimazole for four months. After the treatment with propylthiouracil for another four months, she had been treated with methimazole once again. She was in complete remission for two years. She again experienced symptoms of hyperthyroidism, and treatment with methimazole was started again. On the thirteenth day after treatment, she experienced hypoglycemic attacks with skin eruption. The plasma glucose was 57 mg/dl, 125I-Insulin binding 69%, free IRI 196 microU/ml. The patient had the HLA-DRB1*0406.

摘要

1986年，一名26岁女性被诊断为患有格雷夫斯病，并接受了四个月的甲巯咪唑治疗。在用丙硫氧嘧啶再治疗四个月后，她再次接受了甲巯咪唑治疗。她完全缓解了两年。她再次出现甲状腺功能亢进症状，并再次开始用甲巯咪唑治疗。治疗后第13天，她出现低血糖发作并伴有皮疹。血浆葡萄糖为57mg/dl，125I-胰岛素结合率为69%，游离胰岛素释放指数为196微单位/毫升。该患者具有HLA-DRB1*0406。