钾通道开放剂消除特发性长QT综合征患者的早期后去极化。
Early afterdepolarization abolished by potassium channel opener in a patient with idiopathic long QT syndrome.
作者信息
Sato T, Hata Y, Yamamoto M, Morita H, Mizuo K, Yamanari H, Saito D, Ohe T
机构信息
Department of Cardiovascular Medicine, Okayama University, Japan.
出版信息
J Cardiovasc Electrophysiol. 1995 Apr;6(4):279-82. doi: 10.1111/j.1540-8167.1995.tb00400.x.
We describe a 17-year-old boy with idiopathic long QT syndrome and repeated syncopal episodes. Early afterdepolarization (EAD) in the monophasic action potential (MAP) was demonstrated in the posterior septum of the left ventricle. Injection of the potassium channel opener nicorandil decreased EAD and shortened MAP duration. The syncopal episodes due to ventricular fibrillation disappeared after administration of the potassium channel opener.
我们描述了一名患有特发性长QT综合征且反复出现晕厥发作的17岁男孩。在左心室后间隔的单相动作电位（MAP）中证实了早期后除极（EAD）。注射钾通道开放剂尼可地尔可减少EAD并缩短MAP持续时间。在给予钾通道开放剂后，由室颤引起的晕厥发作消失。
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