Mendlewicz J, Souery D
Service de Psychiatrie, Hôpital Erasme, Bruxelles.
Bull Acad Natl Med. 1995 Apr;179(4):755-64; discussion 764-6.
The present article reviews the basic and recent findings of the genetics in manic-depressive illness. The different molecular genetic techniques that have been applied to this research field are presented. Results of linkage and association studies are discussed in regard to the main limitations of these approaches in psychiatric disorders. On the whole, linkage and association studies contributed to the localisation of some potentials vulnerability genes for manic-depression on chromosomes X and 11 and more recently 18.
本文综述了躁郁症遗传学的基础及最新研究成果。介绍了应用于该研究领域的不同分子遗传学技术。针对这些方法在精神疾病研究中的主要局限性，讨论了连锁研究和关联研究的结果。总体而言，连锁研究和关联研究有助于在X染色体、11号染色体以及最近发现的18号染色体上定位一些躁郁症潜在的易感基因。
