Bréchot C
Laboratoire de Biologie Cellulaire, INSERM U. 370, CHU Necker.
C R Seances Soc Biol Fil. 1995;189(1):87-96.
Cell cycle progression is regulated by the sequential activation of cyclins expression and their association to the cyclin dependent kinases (CDK). Several in vitro and in vivo studies indicate that inappropriate cyclin expression (cyclins D, E, A) in the cell, whether or not due to chromosomal rearrangements, can participate in cell transformation. Thus these studies implicate cyclins in human carcinogenesis.
