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纤连蛋白（FN）可减轻增殖性肾小球肾炎中的肾小球病变，并减少肿瘤坏死因子-α（TNF-α）、血小板活化因子（PAF）和纤连蛋白的合成。

Fibronectin (FN) decreases glomerular lesions and synthesis of tumour necrosis factor-alpha (TNF-alpha), platelet-activating factor (PAF) and FN in proliferative glomerulonephritis.

作者信息

Ortíz A, Alonso J, Gómez-Chiarri M, Lerma J L, Seron D, Condom E, González E, Egido J

机构信息

Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

出版信息

Clin Exp Immunol. 1995 Aug;101(2):334-40. doi: 10.1111/j.1365-2249.1995.tb08360.x.

DOI:10.1111/j.1365-2249.1995.tb08360.x
PMID:7648718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1553248/
Abstract

We have studied the effect of therapy with plasma FN on glomerular synthesis of PAF, TNF-alpha and FN, in experimental proliferative glomerulonephritis. Glomerular PAF, TNF-alpha and FN production were increased in rats with nephritis. Peak glomerular PAF production preceded, while peak glomerular TNF-alpha bioactivity coincided with maximal proteinuria. Rats treated with FN (5 mg/kg per 48 h) for 15 days had less proteinuria, glomerular and interstitial cell infiltration and glomerular PAF, TNF-alpha and FN synthesis than non-treated rats. In order to characterize further the mechanisms of action of FN, healthy rats were injected with either FN or saline. Peripheral blood mononuclear cells and neutrophils from healthy rats injected with FN secreted less TNF-alpha and PAF, respectively, than those obtained from saline-treated rats. Our data suggest that the beneficial effect of FN may be related to decreased number of glomerular leucocytes and decreased synthesis of inflammatory mediators and extracellular matrix.

摘要

我们研究了血浆纤维连接蛋白（FN）治疗对实验性增殖性肾小球肾炎中血小板活化因子（PAF）、肿瘤坏死因子-α（TNF-α）和FN肾小球合成的影响。肾炎大鼠的肾小球PAF、TNF-α和FN生成增加。肾小球PAF生成峰值先于蛋白尿出现，而肾小球TNF-α生物活性峰值与最大蛋白尿同时出现。每48小时给予5mg/kg FN治疗15天的大鼠，其蛋白尿、肾小球和间质细胞浸润以及肾小球PAF、TNF-α和FN合成均少于未治疗大鼠。为了进一步阐明FN的作用机制，给健康大鼠注射FN或生理盐水。与注射生理盐水的大鼠相比，注射FN的健康大鼠外周血单核细胞和中性粒细胞分别分泌较少的TNF-α和PAF。我们的数据表明，FN的有益作用可能与肾小球白细胞数量减少以及炎症介质和细胞外基质合成减少有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daac/1553248/671d07f44073/clinexpimmunol00221-0144-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daac/1553248/1c2d0b1e1fc6/clinexpimmunol00221-0143-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daac/1553248/2a999ee79a67/clinexpimmunol00221-0144-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daac/1553248/671d07f44073/clinexpimmunol00221-0144-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daac/1553248/1c2d0b1e1fc6/clinexpimmunol00221-0143-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daac/1553248/2a999ee79a67/clinexpimmunol00221-0144-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/daac/1553248/671d07f44073/clinexpimmunol00221-0144-b.jpg

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本文引用的文献

1
Expression of IP-10, a lipopolysaccharide- and interferon-gamma-inducible protein, in murine mesangial cells in culture.脂多糖和γ干扰素诱导蛋白IP-10在培养的小鼠系膜细胞中的表达。
Am J Pathol. 1993 Feb;142(2):433-9.
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Fibronectin cell-binding domain triggered transmembrane signal transduction in human monocytes.纤连蛋白细胞结合结构域触发人单核细胞中的跨膜信号转导。
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Involvement of tumor necrosis factor and platelet-activating factor in the pathogenesis of experimental nephrosis in rats.
肿瘤坏死因子和血小板活化因子在大鼠实验性肾病发病机制中的作用。
Lab Invest. 1994 Apr;70(4):449-59.
4
Synthetic fibronectin peptides suppress arthritis in rats by interrupting leukocyte adhesion and recruitment.合成纤连蛋白肽通过阻断白细胞黏附和募集来抑制大鼠关节炎。
J Clin Invest. 1994 Aug;94(2):655-62. doi: 10.1172/JCI117382.
5
TNF-alpha binds to the N-terminal domain of fibronectin and augments the beta 1-integrin-mediated adhesion of CD4+ T lymphocytes to the glycoprotein.肿瘤坏死因子-α与纤连蛋白的N端结构域结合，并增强β1整合素介导的CD4+T淋巴细胞与糖蛋白的黏附。
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Is there a role for specific anti-TNF strategies in glomerular diseases?
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Treatment with a glycosaminoglycan formulation ameliorates experimental diabetic nephropathy.用糖胺聚糖制剂治疗可改善实验性糖尿病肾病。
Kidney Int. 1994 Sep;46(3):797-806. doi: 10.1038/ki.1994.335.
8
Rat serum sickness: possible role of inflammatory mediators allowing deposition of immune complexes in the glomerular basement membrane.大鼠血清病：炎症介质在免疫复合物于肾小球基底膜沉积过程中可能发挥的作用。
Clin Exp Immunol. 1982 Sep;49(3):631-8.
9
Improved high-performance liquid chromatographic method for isolation of platelet-activating factor from other phospholipids.从其他磷脂中分离血小板活化因子的改进高效液相色谱法。
J Chromatogr. 1983 Apr 8;273(2):415-20. doi: 10.1016/s0378-4347(00)80963-9.
10
Presence in normal human urine of a hypotensive and platelet-activating phospholipid.正常人尿液中存在一种具有降压和血小板激活作用的磷脂。
Am J Physiol. 1983 Jun;244(6):F706-11. doi: 10.1152/ajprenal.1983.244.6.F706.