Hacibekiroğlu M, Akçay T
Department of Biochemistry, Cerrahpasa Faculty of Medicine, University of Istanbul, Turkey.
Diabetes Res. 1994;25(4):173-9.
In this study the plasma, erythrocyte, and platelet myo-inositol levels in 24 type I, 24 type II diabetics, and in 15 healthy controls were determined. The diabetics were devided into two groups with microangiopathy (n = 26) and without microangiopathy (n = 22). The plasma, erythrocyte, and platelet myo-inositol levels in the whole diabetic group and control subjects were as follows. Diabetic group: 46.5 +/- 39.8 mumol.l-1 23.3 +/- 19.8 nmol.ml-1, 2.6 +/- 2.8 nmol.ml-1 (10(5) cells)-1.
17.4 +/- 3.7 mumol.l-1, 12.2 +/- 5.2 nmol.ml-1, 1.5 +/- 0.9 nmol.ml-1 (10(5) cells)-1. The values of the diabetic group were significantly higher than the values of the control group (p < 0.01). In patients with HbA1c levels more than 9% plasma, erythrocyte, and platelet myo-inositol values were significantly higher than the values of the group with HbA1C levels less than 9% (p < 0.05, p < 0.05 and p < 0.01). In diabetics without complications plasma and erythrocyte myo-inositol levels were higher than the values of the control group (p < 0.01), whereas there was no significant difference between the platelet myo-inositol values. In diabetics with complication all these three values were higher than those of the control group (p < 0.01, p < 0.01, p < 0.01). The most profound increase in the plasma, erythrocyte, and platelet myo-inositol levels were seen in complicated diabetics with a diabetes duration of 6-10 years (p < 0.01). After 10 years duration the values declined. In the group without complication there was no difference according to the duration of diabetes.
在本研究中，测定了24例I型糖尿病患者、24例II型糖尿病患者以及15名健康对照者的血浆、红细胞和血小板中肌醇水平。糖尿病患者被分为有微血管病变组（n = 26）和无微血管病变组（n = 22）。整个糖尿病组和对照组受试者的血浆、红细胞和血小板肌醇水平如下。糖尿病组：46.5±39.8μmol·l-1、23.3±19.8nmol·ml-1、2.6±2.8nmol·ml-1（10⁵个细胞）⁻¹。
17.4±3.7μmol·l-1、12.2±5.2nmol·ml-1、1.5±0.9nmol·ml-1（10⁵个细胞）⁻¹。糖尿病组的值显著高于对照组的值（p < 0.01）。糖化血红蛋白（HbA1c）水平超过9%的患者，其血浆、红细胞和血小板肌醇值显著高于HbA1c水平低于9%的组（p < 0.05、p < 0.05和p < 0.01）。无并发症的糖尿病患者，其血浆和红细胞肌醇水平高于对照组的值（p < 0.01），而血小板肌醇值之间无显著差异。有并发症的糖尿病患者，这三个值均高于对照组（p < 0.01、p < 0.01、p < 0.01）。血浆、红细胞和血小板肌醇水平升高最显著的是糖尿病病程为6至10年的有并发症糖尿病患者（p < 0.01）。病程10年后，这些值下降。在无并发症组中，根据糖尿病病程无差异。
