Zhang J, Chen W, He X
Sun Yatsen Memorial Hospital, San Yatsen University of Medical Sciences, Guangzhou.
Zhonghua Fu Chan Ke Za Zhi. 1995 May;30(5):284-6.
Seventy three pregnancies in 44 women with systemic lupus erythematosus in our hospital from June 1970 to June 1993 were studied. It included 15 spontaneous abortions (20.55%), 8 induced abortions (10.96%), 9 perinatal fetal deaths (12.33%) and 41 live births (56.16%). Therapy with steroids during pregnancy is harmless and effective. It may reduce pregnant loss rate. Of 41 live births, 35 children were followed up (85.36%). Their physical growth, routine blood test and urinalysis were normal. There were no definite evidences of mental developmental abnormality in children. Two girls had been diagnosed of systemic lupus erythematosus at about nine years old. It is possible that systemic lupus erythematosus may be hereditable to female filial generation. So we suggest that the following-up on children born to mothers with systemic lupus erythematosus have to be done till puberty.
对我院1970年6月至1993年6月期间44例系统性红斑狼疮患者的73次妊娠情况进行了研究。其中包括15例自然流产（20.55%）、8例人工流产（10.96%）、9例围产期胎儿死亡（12.33%）和41例活产（56.16%）。孕期使用类固醇治疗无害且有效。它可能会降低妊娠丢失率。在41例活产中，对35名儿童进行了随访（85.36%）。他们的身体发育、血常规和尿常规均正常。没有明确证据表明儿童存在精神发育异常。两名女孩在9岁左右被诊断为系统性红斑狼疮。系统性红斑狼疮有可能遗传给女性子代。因此，我们建议对系统性红斑狼疮母亲所生子女进行随访直至青春期。
