[Prognosis of filial generation from mothers with systemic lupus erythematosus].

Seventy three pregnancies in 44 women with systemic lupus erythematosus in our hospital from June 1970 to June 1993 were studied. It included 15 spontaneous abortions (20.55%), 8 induced abortions (10.96%), 9 perinatal fetal deaths (12.33%) and 41 live births (56.16%). Therapy with steroids during pregnancy is harmless and effective. It may reduce pregnant loss rate. Of 41 live births, 35 children were followed up (85.36%). Their physical growth, routine blood test and urinalysis were normal. There were no definite evidences of mental developmental abnormality in children. Two girls had been diagnosed of systemic lupus erythematosus at about nine years old. It is possible that systemic lupus erythematosus may be hereditable to female filial generation. So we suggest that the following-up on children born to mothers with systemic lupus erythematosus have to be done till puberty.