多沙普仑在减少大手术后肺部并发症中的作用。
Role of doxapram in reducing pulmonary complications after major surgery.
作者信息
Gawley T H, Dundee J W, Gupta P K, Jones C J
出版信息
Br Med J. 1976 Jan 17;1(6002):122-4. doi: 10.1136/bmj.1.6002.122.
Abstract
In a double-blind study patients given a single dose of doxapram 1-5-2-0 mg/kg combined with morphine postoperatively had a significantly lower incidence of reflex postoperative cough and expectoration of purulent sputum than patients given morphine alone. They also had significantly higher arterial oxygen tensions five days postoperatively. Smaller differences were found with naloxone combined with morphine.
摘要
在一项双盲研究中，术后接受单剂量1 - 5 - 2 - 0毫克/千克多沙普仑与吗啡联合治疗的患者，术后反射性咳嗽和咳出脓性痰的发生率明显低于单独使用吗啡的患者。他们术后五天的动脉血氧分压也明显更高。在纳洛酮与吗啡联合使用时发现的差异较小。
相似文献
1
Role of doxapram in reducing pulmonary complications after major surgery.多沙普仑在减少大手术后肺部并发症中的作用。
Br Med J. 1976 Jan 17;1(6002):122-4. doi: 10.1136/bmj.1.6002.122.
2
Doxapram and postoperative chest complications.多沙普仑与术后胸部并发症
Anaesthesia. 1983 Jan;38(1):3-6. doi: 10.1111/j.1365-2044.1983.tb10364.x.
3
The use of doxapram in the prevention of postoperative pulmonary complications.多沙普仑在预防术后肺部并发症中的应用。
Surg Gynecol Obstet. 1982 Apr;154(4):510-2.
4
Morphine combined with doxapram or naloxone. A study of post-operative pain relief.吗啡联合多沙普仑或纳洛酮。术后疼痛缓解的一项研究。
Anaesthesia. 1974 Jan;29(1):33-9. doi: 10.1111/j.1365-2044.1974.tb00579.x.
5
Proceedings: The role of doxapram in the reduction of pulmonary complications following surgery.会议记录：多沙普仑在减少术后肺部并发症中的作用。
Br J Anaesth. 1975 Aug;47(8):906-7.
6
Effect of doxapram on postoperative pulmonary complications after upper abdominal surgery in high-risk patients.多沙普仑对高危患者上腹部手术后肺部并发症的影响。
Lancet. 1990 Apr 21;335(8695):936-8. doi: 10.1016/0140-6736(90)90998-k.
7
Prevention of postoperative pulmonary complications. Intravenous analgesia combined with doxapram.预防术后肺部并发症。静脉镇痛联合多沙普仑。
J Oslo City Hosp. 1976 Jun;26(6):61-4.
8
Antagonists of morphine-induced respiratory depression. A study in postoperative patients.吗啡诱导呼吸抑制的拮抗剂。一项针对术后患者的研究。
Anaesthesia. 1980 Jan;35(1):17-21. doi: 10.1111/j.1365-2044.1980.tb03714.x.
9
Doxapram and the fractured femur.多沙普仑与股骨骨折
Anaesthesia. 1982 Mar;37(3):301-4. doi: 10.1111/j.1365-2044.1982.tb01103.x.
10
The effect of an infusion of doxapram on morphine analgesia.多沙普仑输注对吗啡镇痛的影响。
Anaesthesia. 1974 Jan;29(1):40-3. doi: 10.1111/j.1365-2044.1974.tb00580.x.
引用本文的文献
1
A new look at the respiratory stimulant doxapram.对呼吸兴奋剂多沙普仑的新审视。
CNS Drug Rev. 2006 Fall-Winter;12(3-4):236-49. doi: 10.1111/j.1527-3458.2006.00236.x.
2
Postoperative pneumonias.术后肺炎
Br Med J (Clin Res Ed). 1982 Jan 30;284(6312):292-3. doi: 10.1136/bmj.284.6312.292.
3
Postoperative chest infections.术后肺部感染
Br Med J. 1978 Feb 25;1(6111):509. doi: 10.1136/bmj.1.6111.509-a.
4
The disposition of intravenous doxapram in man.静脉注射多沙普仑在人体内的处置情况。
Eur J Clin Pharmacol. 1979;16(6):411-6. doi: 10.1007/BF00568202.
5
A pharmacokinetic study of doxapram in patients and volunteers.多沙普仑在患者和志愿者中的药代动力学研究。
Br J Clin Pharmacol. 1979 Jan;7(1):81-7. doi: 10.1111/j.1365-2125.1979.tb00901.x.
本文引用的文献
1
Modification of the analgesic action of pethidine and morphine by three opiate antagonists, a respiratory stimulant (doxapram) and an analeptic (nikethamide); a study using an experimental pain stimulus in man.三种阿片拮抗剂、一种呼吸兴奋剂（多沙普仑）和一种苏醒药（尼可刹米）对哌替啶和吗啡镇痛作用的影响；一项在人体中使用实验性疼痛刺激的研究
Br J Pharmacol. 1973 Jun;48(2):326P.
2
Clinical evaluation of a new electronic spirometer.一种新型电子肺活量计的临床评估
Chest. 1973 Apr;63(4):517-9. doi: 10.1378/chest.63.4.517.
3
The effect of an infusion of doxapram on morphine analgesia.多沙普仑输注对吗啡镇痛的影响。
Anaesthesia. 1974 Jan;29(1):40-3. doi: 10.1111/j.1365-2044.1974.tb00580.x.
4
Morphine combined with doxapram or naloxone. A study of post-operative pain relief.吗啡联合多沙普仑或纳洛酮。术后疼痛缓解的一项研究。
Anaesthesia. 1974 Jan;29(1):33-9. doi: 10.1111/j.1365-2044.1974.tb00579.x.
Zotero 插件