Petersen T I, Kissmeyer-Nielsen P, Laurberg S, Christensen H
Department of Surgery L, University Hospital of Aarhus, Denmark.
Eur Surg Res. 1995;27(4):250-7. doi: 10.1159/000129407.
Age-related differences in the healing of left colonic anastomoses and abdominal incisional wounds were compared between young and old rats. Immediately after surgery the anastomotic strength (suture-binding capacity) was 67% higher in old rats corresponding to a 107% higher collagen content per unit length of left colon compared to young rats. After 2 and 4 days of healing there was no difference in the breaking strength of the anastomoses between young and old rats, although the increase in collagen content of the anastomosed segment was 100% in the young rats and only 35% in the old rats from day 2 to day 4. The healing of the abdominal incisional wounds was, however, impaired in old rats compared to young rats, since the tensile strength and the energy absorption on the 4th postoperative day was 67 and 57% lower, respectively. In conclusion, old rats have impaired skin healing, whereas colonic healing is not affected by age.
比较了年轻大鼠和老年大鼠左结肠吻合口及腹部切口愈合的年龄相关差异。术后即刻，老年大鼠的吻合口强度（缝线结合能力）比年轻大鼠高67%，对应左结肠单位长度的胶原蛋白含量比年轻大鼠高107%。愈合2天和4天后，年轻大鼠和老年大鼠吻合口的断裂强度没有差异，尽管从第2天到第4天，吻合段胶原蛋白含量在年轻大鼠中增加了100%，而在老年大鼠中仅增加了35%。然而，与年轻大鼠相比，老年大鼠腹部切口的愈合受损，因为术后第4天的抗张强度和能量吸收分别降低了67%和57%。总之，老年大鼠的皮肤愈合受损，而结肠愈合不受年龄影响。
