亚油酸代谢物13-羟基十八碳二烯酸调节人多形核白细胞的脱颗粒作用。
The linoleic acid metabolite 13-HODE modulates degranulation of human polymorphonuclear leukocytes.
作者信息
van de Velde M J, Engels F, Henricks P A, Bloemen P G, Nijkamp F P
机构信息
Department of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands.
出版信息
FEBS Lett. 1995 Aug 7;369(2-3):301-4. doi: 10.1016/0014-5793(95)00773-3.
The effect of the linoleic acid metabolite 13-hydroxyoctadecadienoic acid human polymorphonuclear leukocytes (PMNs) was investigated by measuring the expression of CD11b and CD67 on the plasma membrane. 13-HODE (5 microM) by itself induced degranulation of PMNs, but to a lesser extent as compared to PAF and fMLP. In addition, 13-HODE was found to inhibit the PAF-induced degranulation whereas an additive effect on the fMLP-induced PMNs degranulation was observed. These results indicate that 13-HODE can play a modulatory role in degranulation of PMNs.
通过测量质膜上CD11b和CD67的表达，研究了亚油酸代谢物13-羟基十八碳二烯酸对人多形核白细胞（PMN）的影响。13-羟基十八碳二烯酸（5微摩尔）自身可诱导PMN脱颗粒，但与血小板活化因子（PAF）和N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸（fMLP）相比程度较轻。此外，发现13-羟基十八碳二烯酸可抑制PAF诱导的脱颗粒，而观察到其对fMLP诱导的PMN脱颗粒有相加作用。这些结果表明，13-羟基十八碳二烯酸可在PMN脱颗粒中发挥调节作用。
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