Liberini P, Cuello A C
Department of Pharmacology and Therapeutics, McGill University, Montreal, P.Q., Canada.
Funct Neurol. 1995 Jan-Feb;10(1):45-54.
Neuropathological studies are currently providing extensive information upon which to base experimental models of neurodegenerative diseases. While it seems unlikely that a single model encompassing all aspects of degenerative dementia will be developed in the near future, models that are more restricted in their scope can provide useful data about processes which range from cellular to behavioral disturbances. In this article we present recent primate studies revealing that mature basal forebrain cholinergic neurons degenerate as a consequence of the removal of their target. Both fimbria fornix transection and cortical devascularization seem to be useful tools in the assessment of potential neurotrophic and neuroprotective properties of pharmacological agents.
神经病理学研究目前正在提供大量信息，这些信息可作为神经退行性疾病实验模型的基础。虽然在不久的将来似乎不太可能开发出涵盖退行性痴呆所有方面的单一模型，但范围更有限的模型可以提供有关从细胞紊乱到行为紊乱等一系列过程的有用数据。在本文中，我们介绍了最近的灵长类动物研究，这些研究表明，成熟的基底前脑胆碱能神经元会因失去其靶标而退化。穹窿海马伞横断和皮质去血管化似乎都是评估药物潜在神经营养和神经保护特性的有用工具。
