犬类使用环磷酰胺进行免疫抑制。
Immunosuppression with cyclophosphamide in the dog.
作者信息
Putnam C W, Halgrimson C G, Groth C G, Kashiwagi N, Porter K A, Starzl T E
出版信息
Clin Exp Immunol. 1975 Nov;22(2):323-9.
Abstract
Cyclophosphamide significantly diminished the canine humoral antibody response to sheep red blood cells and tended to prevent arterial lesions in renal homografts. However, cyclophosphamide failed to prolong renal homograft survival when administered to dogs as the sole immunosuppressive agent, and it did not add to the effectiveness of azathioprine when given as a supplement to the azathioprine and administered simultaneously or sequentially.
摘要
环磷酰胺显著降低了犬对绵羊红细胞的体液抗体反应，并倾向于预防肾同种异体移植中的动脉病变。然而，当作为唯一的免疫抑制剂给予犬时，环磷酰胺未能延长肾同种异体移植的存活时间，并且当作为硫唑嘌呤的补充剂同时或先后给予时，它并未增加硫唑嘌呤的有效性。
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引用本文的文献
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EFFECT OF CYCLOPHOSPHAMIDE IN THE ADRENALECTOMIZED ANIMAL.环磷酰胺对肾上腺切除动物的影响。
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DIURETIC ACTION OF CYCLOPHOSPHAMIDE IN EXPERIMENTAL ANIMALS.环磷酰胺在实验动物中的利尿作用。
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Transplantation. 1964 Jul;2:475-86. doi: 10.1097/00007890-196407000-00004.
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DOSE-RESPONSE RELATIONSHIPS FOR AGENTS INHIBITING THE IMMUNE RESPONSE.抑制免疫反应的药物的剂量-反应关系。
Immunology. 1964 Jan;7(1):65-71.
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