原发性胆汁性肝硬化与肝脏中携带免疫球蛋白G的细胞亚群的特定变化有关。

Primary biliary cirrhosis is associated with specific changes in liver IgG-bearing cell subpopulations.

作者信息

Torgano G, Vecchi M, Podda M, Zuin M, Arosio E, Battezzati P M, de Franchis R

机构信息

Department of Internal Medicine, Ospedale Policlinico, Milano, Italy.

出版信息

J Hepatol. 1995 May;22(5):545-50. doi: 10.1016/0168-8278(95)80449-8.

DOI:10.1016/0168-8278(95)80449-8

PMID:7650335

Abstract

BACKGROUND/AIMS: The density of total IgG-bearing cells and the distribution of their subclasses were studied in the liver of patients with primary biliary cirrhosis.

METHODS

Immunohistochemistry and computerized image analysis were used to compare liver specimens from 18 patients with primary biliary cirrhosis and 28 with chronic hepatitis of different etiology.

RESULTS

The density of total IgG-bearing cells was similar in the two groups. However, in patients with primary biliary cirrhosis the proportion of IgG3-positive cells was significantly higher than in patients with chronic hepatitis (53 +/- 7% vs. 7.5 +/- 2.4%) (p < 10(-8)). Conversely, IgG1-positive cells were significantly less prevalent in patients with primary biliary cirrhosis than in chronic hepatitis patients (27 +/- 6.9% vs. 68 +/- 7.2%, p < 10(-8)). Stratification of patients with primary biliary cirrhosis according to histology did not show any difference in the distribution of IgG subclasses associated with the progression of disease.

CONCLUSION

These data suggest a pathogenetic role of local IgG3-bearing cells in primary biliary cirrhosis.

摘要

背景/目的：研究原发性胆汁性肝硬化患者肝脏中总IgG阳性细胞的密度及其亚类分布。

方法

采用免疫组织化学和计算机图像分析技术，对比18例原发性胆汁性肝硬化患者和28例不同病因慢性肝炎患者的肝脏标本。

结果

两组中总IgG阳性细胞的密度相似。然而，原发性胆汁性肝硬化患者中IgG3阳性细胞的比例显著高于慢性肝炎患者（53±7%对7.5±2.4%）（p<10⁻⁸）。相反，原发性胆汁性肝硬化患者中IgG1阳性细胞的比例显著低于慢性肝炎患者（27±6.9%对68±7.2%，p<10⁻⁸）。根据组织学对原发性胆汁性肝硬化患者进行分层，未发现与疾病进展相关的IgG亚类分布存在差异。