Vento S, Guella L, Mirandola F, Cainelli F, Di Perri G, Solbiati M, Ferraro T, Concia E
Department of Infectious Diseases, University of Verona, Borgo Trento Hospital, Italy.
Lancet. 1995 Sep 2;346(8975):608-9. doi: 10.1016/s0140-6736(95)91438-2.
During follow-up of healthy relatives of 13 patients with autoimmune hepatitis, seven cases of infectious mononucleosis due to Epstein-Barr virus (EBV) occurred. In two of these seven, before EBV infection, there was a defect in suppressor-inducer T lymphocytes specifically controlling immune responses to the asialoglycoprotein receptor, an antigen expressed on the hepatocyte surface. In these two, antibodies to this autoantigen persisted and increased after infectious mononucleosis, and autoimmune hepatitis developed within 4 months. In susceptible individuals, EBV is a trigger for autoimmune hepatitis.
在对13例自身免疫性肝炎患者的健康亲属进行随访期间，发生了7例由EB病毒（EBV）引起的传染性单核细胞增多症。在这7例中的2例中，在EBV感染之前，特异性控制对去唾液酸糖蛋白受体免疫反应的抑制诱导性T淋巴细胞存在缺陷，去唾液酸糖蛋白受体是一种在肝细胞表面表达的抗原。在这2例中，针对这种自身抗原的抗体在传染性单核细胞增多症后持续存在并增加，且在4个月内发展为自身免疫性肝炎。在易感个体中，EBV是自身免疫性肝炎的一个触发因素。
