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1,3-Bis(2-chloroethyl)-1-nitrosourea as thiol-carbamoylating agent in biological systems.

作者信息

Becker K, Schirmer R H

机构信息

Institut für Biochemie II, Universität Heidelberg, Germany.

出版信息

Methods Enzymol. 1995;251:173-88. doi: 10.1016/0076-6879(95)51120-2.

DOI:10.1016/0076-6879(95)51120-2
PMID:7651196
Abstract
摘要

相似文献

1
1,3-Bis(2-chloroethyl)-1-nitrosourea as thiol-carbamoylating agent in biological systems.1,3-双(2-氯乙基)-1-亚硝基脲作为生物系统中的硫醇-氨基甲酰化剂。
Methods Enzymol. 1995;251:173-88. doi: 10.1016/0076-6879(95)51120-2.
2
Active site-specific inhibition by 1,3-bis(2-chloroethyl)-1-nitrosourea of two genetically homologous flavoenzymes: glutathione reductase and lipoamide dehydrogenase.
J Lab Clin Med. 1985 Apr;105(4):464-71.
3
Mechanism of inhibition of red blood cell glutathione reductase activity by BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea).
Clin Chim Acta. 1979 Mar 1;92(2):147-52. doi: 10.1016/0009-8981(79)90108-6.
4
Glutathione and N-acetylcysteine conjugates of 2-chloroethyl isocyanate. Identification as metabolites of N,N'-bis(2-chloroethyl)-N-nitrosourea in the rat and inhibitory properties toward glutathione reductase in vitro.2-氯乙基异氰酸酯的谷胱甘肽和N-乙酰半胱氨酸结合物。鉴定为大鼠体内N,N'-双(2-氯乙基)-N-亚硝基脲的代谢产物及其对体外谷胱甘肽还原酶的抑制特性。
Chem Res Toxicol. 1993 May-Jun;6(3):376-83. doi: 10.1021/tx00033a020.
5
Inhibition of human glutathione reductase by the nitrosourea drugs 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea. A crystallographic analysis.
Eur J Biochem. 1988 Jan 15;171(1-2):193-8. doi: 10.1111/j.1432-1033.1988.tb13775.x.
6
Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine and BCNU.抗肿瘤前药氯乙亚硝脲和卡莫司汀产生的异氰酸酯对细胞谷胱甘肽还原酶活性的差异抑制作用。
Biochem Pharmacol. 2005 May 15;69(10):1463-72. doi: 10.1016/j.bcp.2005.02.016.
7
Effects of low concentrations of guanidine hydrochloride on pig heart lipoamide dehydrogenase.低浓度盐酸胍对猪心硫辛酰胺脱氢酶的影响。
Biochemistry. 1974 Jul 30;13(16):3263-8. doi: 10.1021/bi00713a013.
8
Glutathione reductase-deficient erythrocytes as host cells of malarial parasites.谷胱甘肽还原酶缺陷型红细胞作为疟原虫的宿主细胞。
Biochem Pharmacol. 1988 Mar 1;37(5):861-5. doi: 10.1016/0006-2952(88)90173-6.
9
Oxidation of glutathione during hydroperoxide metabolism. A study using isolated hepatocytes and the glutathione reductase inhibitor 1,3-bis(2-chloroethyl)-1-nitrosourea.过氧化氢代谢过程中谷胱甘肽的氧化。一项使用分离的肝细胞和谷胱甘肽还原酶抑制剂1,3-双(2-氯乙基)-1-亚硝基脲的研究。
Eur J Biochem. 1984 Feb 1;138(3):459-63. doi: 10.1111/j.1432-1033.1984.tb07938.x.
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Glutathione, cell proliferation, and 1,3-bis-(2-chloroethyl)-1-nitrosourea in K562 leukemia.谷胱甘肽、细胞增殖与1,3 - 双(2 - 氯乙基)- 1 - 亚硝基脲在K562白血病中的作用
J Clin Invest. 1993 Dec;92(6):2761-7. doi: 10.1172/JCI116894.

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Carbamoylating activity associated with the activation of the antitumor agent laromustine inhibits angiogenesis by inducing ASK1-dependent endothelial cell death.与抗肿瘤药物洛莫司汀激活相关的氨甲酰化活性通过诱导ASK1依赖性内皮细胞死亡来抑制血管生成。
PLoS One. 2014 Jul 28;9(7):e103224. doi: 10.1371/journal.pone.0103224. eCollection 2014.
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BCNU-induced gR2 defect mediates S-glutathionylation of Complex I and respiratory uncoupling in myocardium.BCNU 诱导的 gR2 缺陷介导心肌细胞复合体 I 的 S-谷胱甘肽化和呼吸解偶联。
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TGL-mediated lipolysis in Manduca sexta fat body: possible roles for lipoamide-dehydrogenase (LipDH) and high-density lipophorin (HDLp).
TGL 介导的烟青虫脂肪体中的脂肪分解:可能涉及到硫辛酰胺脱氢酶(LipDH)和高密度脂蛋白(HDLp)的作用。
Insect Biochem Mol Biol. 2014 Feb;45:58-68. doi: 10.1016/j.ibmb.2013.12.001. Epub 2013 Dec 12.
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Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress.过氧化氢对三羧酸循环酶的抑制作用:α-酮戊二酸脱氢酶在氧化应激下限制NADH生成中的关键作用。
J Neurosci. 2000 Dec 15;20(24):8972-9. doi: 10.1523/JNEUROSCI.20-24-08972.2000.
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Decreased aortic glutathione levels may contribute to impaired nitric oxide-induced relaxation in hypercholesterolaemia.主动脉谷胱甘肽水平降低可能导致高胆固醇血症中一氧化氮诱导的舒张功能受损。
Br J Pharmacol. 2000 Mar;129(5):1014-20. doi: 10.1038/sj.bjp.0703127.
6
The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli.人胎盘硫氧还蛋白还原酶的作用机制与硫辛酰胺脱氢酶和谷胱甘肽还原酶的作用机制相似,与大肠杆菌硫氧还蛋白还原酶的作用机制不同。
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3621-6. doi: 10.1073/pnas.94.8.3621.