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Glucocorticoid receptor thiols and steroid-binding activity.

作者信息

Simons S S, Pratt W B

机构信息

Steroid Hormones Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

出版信息

Methods Enzymol. 1995;251:406-22. doi: 10.1016/0076-6879(95)51144-x.

DOI:10.1016/0076-6879(95)51144-x
PMID:7651222
Abstract
摘要

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Glucocorticoid receptor thiols and steroid-binding activity.糖皮质激素受体硫醇与类固醇结合活性
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The seven amino acids (547-553) of rat glucocorticoid receptor required for steroid and hsp90 binding contain a functionally independent LXXLL motif that is critical for steroid binding.大鼠糖皮质激素受体与类固醇及热休克蛋白90（hsp90）结合所需的七个氨基酸（547 - 553）包含一个功能独立的LXXLL基序，该基序对类固醇结合至关重要。
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