Lechago J, Black C, Samloff I M
Gastroenterology. 1976 Mar;70(3):429-32.
A patient with long-standing Crohn's disease of the large and small intestine was found to have extensive gastric metaplasia of the ileum. Most metaplastic glands were of the pyloric type, but numerous oxyntic glands with parietal and chief cells were also seen. By immunofluorescence the chief cells contained both the group I and group II pepsinogens, while the pyloric gland cells contained only the group II pepsinogens. Gastric-containing or other endocrine cells were not detected in the metaplastic pyloric and oxyntic glands. The latter findings are consistent with the concept expressed by Pearse that the endocrine and exocrine cells of the gastrointestinal mucosa may originate from different precursor elements during embryogenesis.
一名患有大肠和小肠长期克罗恩病的患者被发现回肠有广泛的胃化生。大多数化生腺体为幽门型，但也可见到许多含有壁细胞和主细胞的泌酸腺。通过免疫荧光法，主细胞同时含有Ⅰ组和Ⅱ组胃蛋白酶原，而幽门腺细胞仅含有Ⅱ组胃蛋白酶原。在化生的幽门腺和泌酸腺中未检测到含胃或其他内分泌细胞。后一发现与Pearse提出的概念一致，即胃肠道黏膜的内分泌和外分泌细胞可能在胚胎发生过程中起源于不同的前体细胞。
