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[Progress in the study of nerve growth factor family and its receptors].

作者信息

Huang B R, Cai L W

机构信息

National Laboratory of Medical Molecular Biology, Peking Union Medical College, Beijing.

出版信息

Sheng Li Ke Xue Jin Zhan. 1995 Apr;26(2):115-20.

PMID:7652509
Abstract

There were several noticeable progress in the study of the neurotrophic factors, their receptors and the neuronal apoptosis. Firstly, several members of the nerve growth factor family have been identified: NGF, BDNF, NT-3 and NT-4/5. Secondly, the relationship between the three-dimensional structure of the NGF and its function and evolution has been revealed. Thirdly, two kinds of the neurotrophin family receptors were characterized, they are low-affinity NGFR (p75 NGFR) and the trk proto-oncogene product such as p140trkA, p145trkB and p145trkC. Induction of apoptosis by the low-affinity NGFR was also found. Finaly it is possible to use the neurotrophin for treating the degenerative neurological illnesses.

摘要

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