Maksymowych W P, Tao S, Li Y, Wing M, Russell A S
Department of Medicine, University of Alberta, Edmonton, Canada.
Tissue Antigens. 1995 May;45(5):328-32. doi: 10.1111/j.1399-0039.1995.tb02462.x.
The objective was to determine the role of the TAP 1 gene in influencing the phenotype of disease in adult patients with ankylosing spondylitis (AS). The distribution of TAP 1 gene alleles was determined using the PCR RFLP method and restriction enzymes Bcl I and Acc I. The study population included 115 HLA-B27 positive patients with well-documented AS and 41 HLA-B27 positive normal controls. No significant difference in distribution of TAP 1 alleles was noted in comparisons of all AS patients with normal controls. However, AS patients with extraspinal disease were noted to have a significantly increased prevalence of the TAP 1B allele (17.0%) as compared to AS patients without extraspinal disease (2.9%) (P = 0.005) or normal controls (1.9%) (P = 0.005). Polymorphism at the TAP 1 locus may influence disease outcome in patients with AS.
目的是确定TAP 1基因在成年强直性脊柱炎（AS）患者疾病表型影响中的作用。使用聚合酶链反应-限制性片段长度多态性（PCR RFLP）方法以及限制性内切酶Bcl I和Acc I来确定TAP 1基因等位基因的分布。研究人群包括115例有充分记录的HLA-B27阳性AS患者和41例HLA-B27阳性正常对照。在所有AS患者与正常对照的比较中，未发现TAP 1等位基因分布有显著差异。然而，与无脊柱外疾病的AS患者（2.9%）或正常对照（1.9%）相比，有脊柱外疾病的AS患者中TAP 1B等位基因的患病率显著增加（17.0%）（P = 0.005）（P = 0.005）。TAP 1基因座的多态性可能影响AS患者的疾病结局。
