Niederkorn J Y, Mayhew E, He Y
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas 75235, USA.
Transplantation. 1995 Aug 27;60(4):348-54. doi: 10.1097/00007890-199508270-00009.
It has been recognized for over a century that the anterior chamber of the eye is endowed with unique immunological properties that permit the long-term survival of histoincompatible grafts that would otherwise be rejected at extraocular sites. Immune privilege in the anterior chamber of the eye has been attributed, at least in part, to the active down regulation of systemic delayed-type hypersensitivity (DTH) that is induced when antigens are introduced into this ocular compartment. The antigen-specific suppression of systemic DTH that is induced by anterior chamber priming has been termed anterior chamber-associated immune deviation (ACAID) and has been demonstrated with a variety of antigens. The present report summarizes a systematic evaluation of various categories of histocompatibility antigens for their capacity to induce ACAID. The results indicate that ACAID can be induced against a wide variety of alloantigens ranging from a single minor histocompatibility antigen (H-Y) to mismatches involving the entire major histocompatibility complex plus multiple minor histocompatibility loci. Further investigation revealed that it was possible to induce suppression of DTH to third-party alloantigens providing the alloantigens introduced into the anterior chamber were coexpressed with the third-party alloantigens on cells used for extraocular immunizations.
一个多世纪以来，人们已经认识到眼球前房具有独特的免疫特性，能使组织相容性不相容的移植物长期存活，而这些移植物在眼外部位会被排斥。眼内前房的免疫赦免至少部分归因于当抗原被引入这个眼内区域时所诱导的全身迟发型超敏反应（DTH）的主动下调。前房致敏所诱导的对全身DTH的抗原特异性抑制被称为前房相关免疫偏离（ACAID），并且已在多种抗原中得到证实。本报告总结了对各类组织相容性抗原诱导ACAID能力的系统评估。结果表明，ACAID可针对多种同种异体抗原诱导产生，范围从单一的次要组织相容性抗原（H-Y）到涉及整个主要组织相容性复合体以及多个次要组织相容性位点的错配。进一步研究发现，如果引入前房的同种异体抗原与用于眼外免疫的细胞上的第三方同种异体抗原共同表达，就有可能诱导对第三方同种异体抗原的DTH抑制。
