Briko N I, Zhukov V V, Dynga L O, Eshchina A S, Knol H, Gerlach D, Keller W, Beliakov V D
Zh Mikrobiol Epidemiol Immunobiol. 1995 Mar-Apr(2):34-9.
The capacity of Streptococcus pyogenes, isolated from clinically healthy children in a large organized group, for producing erythrogenic toxin A, B and C was studied. The dynamics of toxin production was compared with changes in the levels of morbidity and carrier state, as well as with some characteristics of the interaction between the populations of the infective agent and the host by such values as virulence and susceptibility. Similarity in the dynamics of the parameters under study was noted. The seasonal dynamics of characteristics which determined the capacity for toxin production significantly influenced the levels and one year morbidity dynamics with respiratory streptococcal infection. The study demonstrated the information value of the characteristics of toxin production for understanding both the interval mechanisms of the epidemic process and the influence of the external ones on subsequent epidemic situation.
对从一个大型有组织群体中临床健康儿童分离出的化脓性链球菌产生A、B和C型红疹毒素的能力进行了研究。将毒素产生的动态与发病率和带菌状态水平的变化进行了比较，并通过毒力和易感性等数值，将其与感染因子和宿主群体之间相互作用的一些特征进行了比较。注意到所研究参数动态的相似性。决定毒素产生能力的特征的季节性动态显著影响呼吸道链球菌感染的水平和一年发病率动态。该研究证明了毒素产生特征对于理解流行过程的内部机制以及外部因素对后续疫情形势影响的信息价值。
