[毛细胞白血病及其2-氯脱氧腺苷（2-CdA）治疗]
[Hairy cell leukemia and its treatment with 2-chlorodeoxyadenosine (2-CdA)].
作者信息
Pawelski S
机构信息
Instytutu Hematologii i Transfuzjologii w Warszawie.
出版信息
Acta Haematol Pol. 1995;26(2):139-43.
PMID:7653218
Abstract
In the last years a great progress was observed in the treatment of hairy cell leukaemia due to the introduction of interferon-alfa, pentostatin and above all -2-CdA. Through the programmed death - apoptosis of the hairy lymphocytes 2-CdA causes after 1-2 courses of treatment complete remissions in about 85% of previously treated as well as untreated patients. In the majority of them there are no symptoms of minimal residual disease and probability of their cure is significant.
摘要
在过去几年中，由于干扰素-α、喷司他丁尤其是2-氯脱氧腺苷（2-CdA）的引入，毛细胞白血病的治疗取得了巨大进展。通过毛细胞的程序性死亡——凋亡，2-CdA在1 - 2个疗程的治疗后，可使约85%先前接受过治疗以及未接受过治疗的患者实现完全缓解。其中大多数患者没有微小残留病的症状，治愈的可能性很大。
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